PreValidation Center - Obtain a specific mixing result in a challenging application
Our PreValidation Center in Sweden is equipped with a wide range of mixers optimized for specific unit operations, test vessels up to 5000L, and steam facilities that enable us to offer flexible trial packages. These packages allow you to simulate your mixing process so you can identify how best to perform the job.
The Bioprocess Manufacturing Sciences Group (BMSG) in Billerica, MA, comprises a laboratory that enables simulation of full-scale bioprocess operations. The facility supports all NovAseptic products and serves as an alternative location for PreValidation services for customers in North America.
The trial portfolio includes comparative studies, particle downsizing, emulsification efficiency as well as optimization of mixing efficiency and suspension of solids. Mixer selection tools and prediction models are frequently used by our experts
PreValidation On-Site Trials - A convenient way to optimize an existing process
This is your simplest alternative for evaluating mixing solutions in an existing process. A toolbox of mobile mixing solutions - including mobile transparent tanks, high-shear mixers, upstream mixers and GMP mixers - is at your disposal. This provides you with the flexibility to evaluate new mixing technologies in your production environment and even in your process, if required. When considering retrofitting an existing process for a new mixing purpose or building multi-product capability, our modularized product platforms make on-site trials easy. Our experienced staff of application experts is available for support in the trials.
Avoid Costly Surprises
A challenging mixing process: high amounts of floating powder added to low levels of liquid was evaluated in the PreValidation Center. The best solution for optimal drainability and mixing was found to be a combination of a tulip shaped tank and a NovAseptic GMP Mixer. The best design of the vessel, positioning of the mixer, point of addition of the powder as well as selection of the required mixer size were all captured in the design process, before capital investments.
Get it right from the start by identifying the best solution early in the design process. Your also have the option of evaluating a new mixing technology on-site before installing it in your process.
Simulations in the PreValidation Center have shown that by selecting the appropriate mixer solution, the total mixing time can be reduced by as much as several hours, for example, in buffer preparation processes.
Investing in trials that help you determine the most effective solution in terms of cleanability and mixing saves time – time that can be used to increase your production.
Benefit from Fexibility
Minimum batch sizes were the limiting factor when a customer was designing a new mixing process in existing vessels. Trials performed at Millipore showed that combining a high shear mixer (HS) and a low shear mixer (GMP) allowed batch sizes even smaller than requested. The HS dissolves the powder, the GMP provides mixing. These findings mean the vessels can be used for making several products – an investment in flexibility.
Several mixer solution options and parameters can be included in tailor made trials. You can choose whether these take place in our PreValidation Center or on-site at your facility. We will work with you to design trials to help determine what mixing solution will achieve your desired performance results.
Mixing Test in PreValidation Center
Complete GMP, HS, HSI & USM series.
Mixing Test run by Millipore at the Customer Site
GMP500, HS T60 & USM T60 series.
Customer Rent Test Equipment:
Contact STI Technical Services for details.